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ATLANTA GENOME PROJECT

What is the Atlanta Genome Project?

For indiviuals who are interested in doing more than just the recommended screening tests, this service is for you. 

The mission of the Atlanta Genome Project is to offer available DNA/RNA technologies and research to improve health and quality of life for our patients. Many of us are worried about our  family history, diet, lifestyle and other habits . Lets do something about it. 

Reported associations with cancer and major diseases

A strong family history – can lead to almost all cancers. 

A history of inflammatory bowel disease, Crohn’s disease and ulcerative colitis have a strong association with colon cancer after 10 years of disease.  

Individuals with chronic liver diseases such as Fatty Liver, Hepatitis B and C  have an elevated risk of  liver cancer

Obesity – seems to raise the risk for multiple cancers, as well as heart disease and diabetes

Chronic heartburn and a condition known as, Barrett’s esophagus may significantly raise the risk of esophageal cancer

Men over 50 – prostate cancer

Women over 40 – breast ,  ovarian, uterine Cancers

Our goal is to be aware of these associations and take early action when possible. Genomic analysis ,early screening and early interventions is our best hope to lower risk. 

 

What DNA Technologies are aVailable

We are fortunate to work with our scientific advisor, King Jordan PhD director of the Jordan Lab at the Georgia Insititute of Technology

The Atlanta Genome project is interested in any technology that may help us detect elevated risk for cancers  and disease. 

We currently utilzes a wide variety of tests to discover DNA changes that were either inherited or acquired over time

Inherited mutations

DNA methylation 

Tumor and other biomarkers

 

“The genetic basis of common diseases like diabetes, cancer, heart disease, inflammatory bowel disease, and Alzheimer’s disease is complex. Rarely is one gene mutation the cause of an illness.” Dr Jordan

  

 

How reliable is Genomic Testing?

Most diseases appear to be related to a complex network of abnormal genes interacting in a way that predisposes to future illness. Researchers are now studying this vast interplay of abnormal gene clusters analyzing millions of gene mutations to derive a ‘polygenic association”.

Like most tests, genomic profiling is not an absolute predictor of disease and should never be acted upon without the advice of a physician. The best use of these technologies will be to help identify individuals who would benefit from an early screening tests.

Genomic testing may serve as an added motivation to lower risk factors through diet, lifestyle, and earlier medical screening. 

What is a polygenic risk scores (PRS)?

From Dr Jordan

“Wouldnt it be helpful to have a score card showing your risk factors for cancer and other major diseases. Even better, an action plan to lower that risk long before disease can strike. That is the true goal of the Atlanta Genome Project. 

The Jordan Lab is very interested in a new technology known as polygenic risk profiling (PRS). To understand PRS, we must understand the science of Genome-wide Association Studies (GWAS). These large-scale studies compare the frequency of several hundred thousand common genetic variants between a group of people with a given disease/trait.

These studies then compare findings with a normal population of individuals without the disease. Gene mutations identified in the disease group that are not found in the normal population are considered to be “associated” with the disease. Exactly how we don’t know, but they are clearly found more often in patients with the illness or condition.

Neighborhood Gastroenterology & Nutrition works closely with the scientists at the Jordan Lab to develop new ideas and offer cutting edge technologies like polygenic testing for our patients.

Our Process

Early identification of risk factors is the core principle guiding all medical therapy. Preventing disease is far preferable to treating disease and its complications. 

Our patients receive the following care:

Medical Evaluation and Screening

Review Family History

Lab Testing

Lifestyle/ Nutrition Assessment

Genomic Testing

Research Opportunities

Possible additional testing – CT scan, MRI, PET scan, Endoscopy, Nutrient and Antioxidant testing, and others

Personalized Plan to reduce disease risk 

Referral to other specialists based on individual Risk Scores

If you are interested in an evaluation focused on reducing your risk of future disease consider a visit with the Atlanta Genome Project .